Fanconi’s Anemia among Sudanese Children: A Report of Forty Cases
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چکیده
Fanconi’s anemia (FA) is the most frequent inherited cause of Bone Marrow Failure (BMF) [1]. It is transmitted through both autosomal and X-linked recessive modes [2]. It affects all ethnic groups. It is characterized by congenital malformations, progressive marrow failure and predisposition to acute myelogenous leukemia (AML) and other malignancies [3]. The hypersensitivity to DNA cross-linking agents such as diepoxybutane (DEB) is used as a diagnostic test for this disease. Currently Hematopoietic Stem Cell Transplantation (HSCT) is the best treatment to cure severe aplastic anemia [4,5]. This study aimed to review the demographic and clinical features of FA and to assess their outcome. Method
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تاریخ انتشار 2016